Genome transfer for the prevention of female

september 9, 2020 Leave a comment

Genome transfer for the prevention of female infertility caused by maternal gene mutation

Poor oocyte quality is associated with early embryo developmental arrest and infertility. Maternal gene plays crucial roles in the regulation of oocyte maturation, and its mutation is a common cause of female infertility. However, how to improve oocyte quality and develop effective therapy for maternal gene mutation remains elusive. Here, we use Zar1 as an example to assess the feasibility of genome transfer to cure maternal gene mutation-caused female infertility. We first discover that cytoplasmic deficiency primarily leads to Zar1-null embryo developmental arrest by disturbing maternal transcript degradation and minor zygotic genome activation (ZGA) during the maternal-zygotic transition.
We next perform genome transfer at the oocyte (spindle transfer or polar body transfer) and zygote (early pronuclear transfer or late pronuclear transfer) stages to validate the feasibility of preventing Zar1 mutation-caused infertility. We finally demonstrate that genome transfer either at the oocyte or at the early pronuclear stage can support normal preimplantation embryo development and produce live offspring. Moreover, those pups grow to adulthood and show normal fertility. Therefore, our findings provide an effective basis of therapies for the treatment of female infertility caused by maternal gene mutation.
genecorner
genecorner

HIV-1 p24 recombinant antigen
8909 100 ug
EUR 608.1
Description: This is HIV-1 p24 recombinant antigen for ELISA,WB.

HIV-1 p24 recombinant antigen.
00174-V 1 MG
EUR 850

HIV-1 p24 recombinant antigen,
00174-V-01mg 0,1 mg
EUR 321
Description: HIV-1 p24 recombinant antigen.

HIV-1 p24 recombinant antigen,
00174-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 p24 recombinant antigen.

HIV-1 p24 recombinant antigen.
00174-V-100ugvial 100ug/vial
EUR 150
Description: HIV-1 p24 recombinant antigen.

HIV-1 p24 recombinant antigen.
MBS485187-01mg 0.1mg
EUR 300

HIV-1 p24 recombinant antigen.
MBS485187-1mg 1mg
EUR 1300

HIV-1 p24 recombinant antigen.
MBS485187-5x1mg 5x1mg
EUR 5795

Human HIV-1 And HIV-2 Plus P24 Antigen Fourth-Generation (HIV p24 antigen) ELISA Kit
abx257575-96tests 96 tests
EUR 764.4

HIV-1 gag p24 antigen (RECOMBINANT)
HI1A-720-4 50ug
EUR 295

HIV-1 gag p24 antigen (RECOMBINANT)
HI1A-720-5 100ug
EUR 495

Astrovirus Antigen (Type 1)
AS02-1000 1.0
EUR 1654.65
Description: A concentrated source of Astrovirus particles and Astrovirus proteins from a lysate of host cells.

Astrovirus Antigen (Type 1)
AS02-200 0.2
EUR 442.69
Description: A concentrated source of Astrovirus particles and Astrovirus proteins from a lysate of host cells.

HIV-1 GAG P24 Recombinant Antigen
00111-V-01mg 0,1 mg
EUR 321
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 GAG P24 Recombinant Antigen
00111-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

Recombinant HIV-1 p24 Core Antigen
HIV-277 1 vial
EUR 798.4
Description: Protein

HIV-1 p17-p24 recombinant antigen.
00172-V 1 MG
EUR 850

HIV-1 p17-p24 recombinant antigen.
00172-V-100ugvial 100ug/vial
EUR 150
Description: HIV-1 p17-p24 recombinant antigen.

HIV-1 p17-p24 recombinant antigen.
MBS485154-01mg 0.1mg
EUR 300

HIV-1 p17-p24 recombinant antigen.
MBS485154-1mg 1mg
EUR 1300

HIV-1 p17-p24 recombinant antigen.
MBS485154-5x1mg 5x1mg
EUR 5795

HIV type 1 P24
DAG1520 100 µg
EUR 972

HIV Type-1 p24 Antibody
V2344-100UG 100 ug
EUR 424.15
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody
V2344-20UG 20 ug
EUR 186.15
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody
V2344CF488-100T 100 Tests
EUR 424.15
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody
V2344SAF-100UG 100 ug
EUR 424.15
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV 1 p24 core recombinant antigen.
00177-V 1 MG
EUR 850

HIV 1 p24 core recombinant antigen
00177-V-01mg 0,1 mg
EUR 321
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen
00177-V-1000ug 1000 ug
EUR 1539
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen.
00177-V-100ugvial 100ug/vial
EUR 150
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen.
MBS485109-01mg 0.1mg
EUR 300

HIV 1 p24 core recombinant antigen.
MBS485109-1mg 1mg
EUR 1300

HIV 1 p24 core recombinant antigen.
MBS485109-5x1mg 5x1mg
EUR 5795

Antibody against HIV P24 antigen
MBS478168-10mg 10mg
EUR 1560

Antibody against HIV P24 antigen
MBS478168-1mg 1mg
EUR 275

Antibody against HIV P24 antigen
MBS478168-20mg 20mg
EUR 2570

Antibody against HIV P24 antigen
MBS478168-50mg 50mg
EUR 6185

Antibody against HIV P24 antigen
MBS478168-5mg 5mg
EUR 840

Antibody against HIV P24 antigen
MBS478169-10mg 10mg
EUR 1560

Antibody against HIV P24 antigen
MBS478169-1mg 1mg
EUR 275

Antibody against HIV P24 antigen
MBS478169-20mg 20mg
EUR 2570

Antibody against HIV P24 antigen
MBS478169-50mg 50mg
EUR 6185

Antibody against HIV P24 antigen
MBS478169-5mg 5mg
EUR 840

Antibody against HIV P24 antigen
MBS478170-10mg 10mg
EUR 1560

Antibody against HIV P24 antigen
MBS478170-1mg 1mg
EUR 275

Antibody against HIV P24 antigen
MBS478170-20mg 20mg
EUR 2570

Antibody against HIV P24 antigen
MBS478170-50mg 50mg
EUR 6185

Antibody against HIV P24 antigen
MBS478170-5mg 5mg
EUR 840

Antibody against HIV P24 antigen
MBS478171-10mg 10mg
EUR 1560

Antibody against HIV P24 antigen
MBS478171-1mg 1mg
EUR 275

Antibody against HIV P24 antigen
MBS478171-20mg 20mg
EUR 2570

Antibody against HIV P24 antigen
MBS478171-50mg 50mg
EUR 6185

Antibody against HIV P24 antigen
MBS478171-5mg 5mg
EUR 840

Recombinant HIV-1 p24 Antigen, His-tagged
HIV-276 1 vial
EUR 798.4
Description: Protein

Recombinant HIV-1 p24 Antigen, His-tagged
HIV-281 1 vial
EUR 798.4
Description: Protein

HIV type 1 P24 [GST]
DAG1516 100 µg
EUR 774

HIV type 1 P24 [His]
DAG1518 100 µg
EUR 774

HIV type 1 P24 [His]
DAG1799 50 ug
EUR 2017.2

HIV type 1 P24 [His]
DAG2375 100 µg
EUR 868.8

HIV type 1 P24 [His]
DAG2377 100 µg
EUR 868.8

HIV-1 gag p24 antigen IgG fraction (monoclonal)
HI1M-721-5 100ug
EUR 425

HIV type 1 p24 [FITC]
DAGH004 50 Tests
EUR 1112.4

HIV type 1 P24 [Biotin]
DAG1519 100 µg
EUR 972

Mouse Anti Human Immunodeficiency Virus (HIV-1) p24 (1947)
MAB12321-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for HIV-1 p24

Mouse Anti Human Immunodeficiency Virus (HIV-1) p24 (1947)
MAB12321-500 0.5
EUR 671.04
Description: Mouse monoclonal antibody specific for HIV-1 p24

HIV type O envelope antigen
00178-V-01mg 0,1 mg
EUR 321
Description: HIV type O envelope antigen. Synthetic HIV type-O peptide, containing the HIV type-O envelope-derived sequence.

HIV type O envelope antigen
00178-V-1000ug 1000 ug
EUR 1539
Description: HIV type O envelope antigen. Synthetic HIV type-O peptide, containing the HIV type-O envelope-derived sequence.

HIV-P24 antigen array kit
VArk-Lsx001 unit Ask for price
Description: Fourth-generation HIV immunoassays detect viral p24 protein in the blood.

Recombinant HIV type 1 gp41 Antigen, Coating
DAG-WT1177 1 mg
EUR 420
Description: Recombinant

Recombinant HIV type 1 gp41 Antigen, Detection
DAG-WT1178 1 mg
EUR 420
Description: Recombinant

HIV type 1 P24 (p24HXBc2) [His]
DAG2378 100 µg
EUR 1095.6

Recombinant HIV-1 p24 Antigen, GST-tagged, HRP-Labled
HIV-282 1 vial
EUR 798.4
Description: Protein

HIV type 1 P24 (CN54) [His]
DAG2380 100 µg
EUR 1095.6

HIV type 1 P24 (HXBc2) [His]
DAG2376 100 µg
EUR 868.8

Human Immunodeficiency Virus (HIV) p24 Antigen >95%
MBS568670-1mg 1mg
EUR 2175

Human Immunodeficiency Virus (HIV) p24 Antigen >95%
MBS568670-5x1mg 5x1mg
EUR 9585

Recombinant HIV-1 gag p17 and p24 Antigen, GST-tagged
PT2-332 1 vial
EUR 798.4
Description: Protein

Human Immunodeficiency Virus p24 Protein [HIV-1/Clade B]
REC31743-100 0.1
EUR 496.27
Description: Recombinant HIV p24 protein (NCBI accession number ABO61536, AA35-265, L40I) produced in HEK293 cells. Protein carries a C-terminal His-tag.. Protein was purified by immobilised metal affinity and ion exchange chromatography from the pellet of transfected cells.

Human Immunodeficiency Virus p24 Protein [HIV-1/Clade B]
REC31743-500 0.5
EUR 1363.78
Description: Recombinant HIV p24 protein (NCBI accession number ABO61536, AA35-265, L40I) produced in HEK293 cells. Protein carries a C-terminal His-tag.. Protein was purified by immobilised metal affinity and ion exchange chromatography from the pellet of transfected cells.

Human Immunodeficiency Virus P24 Protein [HIV-1/Clade C]
REC31706-100 0.1
EUR 457.08
Description: Recombinant HIV-1 p24 produced in E. coli with a 6x histidine tag.

Human Immunodeficiency Virus P24 Protein [HIV-1/Clade C]
REC31706-500 0.5
EUR 1167.82
Description: Recombinant HIV-1 p24 produced in E. coli with a 6x histidine tag.

Human Immunodeficiency Virus type 1 (HIV-1) Gag-p24 Antibody, Rabbit PAb, Antigen Affinity Purified
MBS8105661-002mL 0.02mL
EUR 185

Human Immunodeficiency Virus type 1 (HIV-1) Gag-p24 Antibody, Rabbit PAb, Antigen Affinity Purified
MBS8105661-01mL 0.1mL
EUR 415

Human Immunodeficiency Virus type 1 (HIV-1) Gag-p24 Antibody, Rabbit PAb, Antigen Affinity Purified
MBS8105661-5x01mL 5x0.1mL
EUR 1710

Recombinant HIV-1 p24 gag Antigen, beta-galactosidase-tagged
HIV-278 1 vial
EUR 798.4
Description: Protein

A novel fumarate, isosorbide di-(methyl fumarate) (IDMF), replicates astrocyte transcriptome responses to dimethyl fumarate (DMF) but specifically down-regulates genes linked to a reactive phenotype

Dimethyl fumarate (DMF) has emerged as a first-line treatment for the relapsing-remitting multiple sclerosis (RRMS) subtype. It is hypothesized that DMF has anti-inflammatory and antioxidant effects although mechanisms are not fully understood. This study used RNA-seq to profile gene expression responses to DMF in cultured astrocytes. Responses were compared with those of isosorbide di-(methyl fumarate) (IDMF), a newly designed fumarate that may partially replicate DMF activity with fewer adverse effects. Both compounds altered the expression of MS-associated genes, including those near MS susceptibility loci and genes dysregulated in MS patient astrocytes.
The shared DMF/IDMF transcriptome response involved altered expression of antioxidant genes (e.g., HMOX1) and genes linked to extracellular matrix integrity (TIMP3, MMP9) and migration of pro-inflammatory cells into CNS (CCL2). IDMF-specific transcriptome responses included down-regulation of mitotic genes associated with a proliferative reactive astrocyte phenotype (ICAM1) and repression of genes encoding NF-kappaB subunits (NFKB2, RELA, RELB) and NF-kappaB targets (NCAPG, CXCL1, OAS3). Overall, these results identify astrocyte-centered mechanisms that may contribute to the established efficacy of DMF as an RRMS treatment. Furthermore, our findings support a rationale for further studies of IDMF as a novel fumarate, which may have unique suppressive effects on astrocyte reactivity and glial scar formation. [200 words].

Changes in peripheral blood oxidative stress markers and hepatic gene expression related to oxidative stress in Holstein cows with and without subacute ruminal acidosis during the periparturient period

We investigated changes in peripheral blood metabolites, oxidative stress markers (malondialdehyde, potential antioxidant capacity, and glutathione peroxidase [GPX]), and hepatic gene expression related to oxidative stress in Holstein cows with and without subacute ruminal acidosis (SARA) during the periparturient period. Eighteen multiparous Holstein cows were categorized into SARA (n=9) or non-SARA (n=9) groups depending on whether they developed SARA; reticulo-ruminal pH was <5.6 for more than 3 hr per day, during the 2 weeks after parturition. Blood and liver tissue samples were collected 3 weeks prepartum and 2 and 6 weeks postpartum, with an additional blood sample collected 0 and 4 weeks postpartum.
Blood aspartate transaminase (AST) and nonesterified fatty acid (NEFA) increased significantly (P<0.05) after parturition in both groups. GPX activity decreased gradually after parturition in the SARA group. In the SARA group, gene expression of GPX 1 and microsomal glutathione S-transferase 3 (MGST3) decreased significantly (P<0.05), and expression of metallothionein 2A increased significantly (P<0.05) after parturition in the SARA group. Superoxide dismutase 1 and MGST3 decreased significantly (P<0.05) 2 weeks postpartum in the non-SARA group. Gene expression related to oxidative stress was negatively correlated with AST, NEFA and total ketone body levels. Therefore, the hepatic gene expression related to oxidative stress might change associated with a negative energy balance, and might relate the high oxidative stress in the SARA group during periparturient period.

PSMB8 Antibody
E94054 100μg
EUR 255
Description: Available in various conjugation types.

PSMB8 Antibody
E97340 100ul
EUR 255
Description: Available in various conjugation types.

PSMB8 Antibody
E314816 100ug/200ul
EUR 295
Description: Available in various conjugation types.

PSMB8 antibody
70R-13550 100 ul
EUR 550
Description: Affinity purified Rabbit polyclonal PSMB8 antibody

PSMB8 antibody
70R-19589 50 ul
EUR 289
Description: Rabbit polyclonal PSMB8 antibody

PSMB8 Antibody
1-CSB-PA116429
  • Ask for price
  • Ask for price
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

PSMB8 antibody
BF0434 100ug
EUR 355

PSMB8 Antibody
MBS7113266-005mL 0.05mL
EUR 190

PSMB8 Antibody
MBS7113266-01mL 0.1mL
EUR 270

PSMB8 Antibody
MBS7113266-5x01mL 5x0.1mL
EUR 1205

PSMB8 Antibody
MBS7129229-005mL 0.05mL
EUR 190

PSMB8 Antibody
MBS7129229-01mL 0.1mL
EUR 270

PSMB8 Antibody
MBS7129229-5x01mL 5x0.1mL
EUR 1205

PSMB8 Antibody
MBS7129230-005mL 0.05mL
EUR 190

PSMB8 Antibody
MBS7129230-01mL 0.1mL
EUR 270

PSMB8 Antibody
MBS7129230-5x01mL 5x0.1mL
EUR 1205

PSMB8 antibody
MBS9405580-01mL 0.1mL
EUR 420

PSMB8 antibody
MBS9405580-5x01mL 5x0.1mL
EUR 1740

PSMB8 Antibody
MBS8500013-01mg 0.1mg
EUR 325

PSMB8 Antibody
MBS8500013-01mLAF405L 0.1mL(AF405L)
EUR 565

PSMB8 Antibody
MBS8500013-01mLAF405S 0.1mL(AF405S)
EUR 565

PSMB8 Antibody
MBS8500013-01mLAF610 0.1mL(AF610)
EUR 565

PSMB8 Antibody
MBS8500013-01mLAF635 0.1mL(AF635)
EUR 565

PSMB8 Antibody
MBS5312424-01mL 0.1mL
EUR 1070

PSMB8 Antibody
MBS5312424-5x01mL 5x0.1mL
EUR 4655

PSMB8 Antibody
MBS9416351-01mL 0.1mL
EUR 305

PSMB8 Antibody
MBS9416351-5x01mL 5x0.1mL
EUR 1230

PSMB8 Antibody
BF0434-100ul 100ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA

PSMB8 Antibody
BF0434-200ul 200ul Ask for price
Description: WB,IHC,IF/ICC,ELISA

PSMB8 Antibody
BF0434-50ul 50ul
EUR 150
Description: WB,IHC,IF/ICC,ELISA

PSMB8 Conjugated Antibody
C43134 100ul
EUR 476.4

PSMB8 Polyclonal Antibody
E-AB-92394-120uL 120uL
EUR 320
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-92394-200uL 200uL
EUR 530
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-92394-60uL 60uL
EUR 200
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-92394-each each Ask for price
Description: Unconjugated

PSMB8 Polyclonal Antibody
A73468 50 μl
EUR 557

PSMB8 Polyclonal Antibody
E-AB-61655-120uL 120uL
EUR 320
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-61655-200uL 200uL
EUR 530
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-61655-60uL 60uL
EUR 200
Description: Unconjugated

PSMB8 Polyclonal Antibody
E-AB-61655-each each Ask for price
Description: Unconjugated

PSMB8 Polyclonal Antibody
MBS2538339-006mL 0.06mL
EUR 190

PSMB8 Polyclonal Antibody
MBS2538339-012mL 0.12mL
EUR 265

PSMB8 Polyclonal Antibody
MBS2538339-02mL 0.2mL
EUR 415

PSMB8 Polyclonal Antibody
MBS2538339-5x02mL 5x0.2mL
EUR 1835

PSMB8 Polyclonal Antibody
MBS2527805-002mL 0.02mL
EUR 140

PSMB8 Polyclonal Antibody
MBS2527805-006mL 0.06mL
EUR 180

PSMB8 Polyclonal Antibody
MBS2527805-012mL 0.12mL
EUR 260

PSMB8 Polyclonal Antibody
MBS2527805-02mL 0.2mL
EUR 405

PSMB8 Polyclonal Antibody
MBS2527805-5x02mL 5x0.2mL
EUR 1725

PSMB8 Polyclonal Antibody
MBS2528965-002mL 0.02mL
EUR 140

PSMB8 Polyclonal Antibody
MBS2528965-006mL 0.06mL
EUR 180

PSMB8 Polyclonal Antibody
MBS2528965-012mL 0.12mL
EUR 260

PSMB8 Polyclonal Antibody
MBS2528965-02mL 0.2mL
EUR 405

PSMB8 Polyclonal Antibody
MBS2528965-5x02mL 5x0.2mL
EUR 1725

PSMB8 Conjugated Antibody
MBS9451453-01mLAF350 0.1mL(AF350)
EUR 480

PSMB8 Conjugated Antibody
MBS9451453-01mLAF405 0.1mL(AF405)
EUR 480

PSMB8 Conjugated Antibody
MBS9451453-01mLAF488 0.1mL(AF488)
EUR 480

PSMB8 Conjugated Antibody
MBS9451453-01mLAF555 0.1mL(AF555)
EUR 480

PSMB8 Conjugated Antibody
MBS9451453-01mLBiotin 0.1mL(Biotin)
EUR 480

PSMB8 Polyclonal Antibody
RD84433A-120uL 120μL
EUR 360
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

PSMB8 Polyclonal Antibody
RD84433A-200uL 200μL
EUR 630
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

PSMB8 Polyclonal Antibody
RD84433A-60uL 60μL
EUR 204
Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

PSMB8 Antibody (N-term)
MBS9213569-008mL 0.08mL
EUR 210

PSMB8 Antibody (N-term)
MBS9213569-04mL 0.4mL
EUR 430

PSMB8 Antibody (N-term)
MBS9213569-5x04mL 5x0.4mL
EUR 1910

PSMB8 Antibody, HRP conjugated
1-CSB-PA018886LB01HU
  • Ask for price
  • Ask for price
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PSMB8 Antibody, HRP Conjugated
MBS7113267-005mL 0.05mL
EUR 190

PSMB8 Antibody, HRP Conjugated
MBS7113267-01mL 0.1mL
EUR 270

PSMB8 Antibody, HRP Conjugated
MBS7113267-5x01mL 5x0.1mL
EUR 1205

PSMB8 Antibody, FITC conjugated
1-CSB-PA018886LC01HU
  • Ask for price
  • Ask for price
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OACD05288-1ML - PSMB8 Antibody
OACD05288-1ML 1ml
EUR 649

OACD05289-1ML - PSMB8 Antibody
OACD05289-1ML 1ml
EUR 659

OACD05290-1ML - PSMB8 Antibody
OACD05290-1ML 1ml
EUR 639

PSMB8 Antibody, FITC Conjugated
MBS7113268-005mL 0.05mL
EUR 190

PSMB8 Antibody, FITC Conjugated
MBS7113268-01mL 0.1mL
EUR 270

PSMB8 Antibody, FITC Conjugated
MBS7113268-5x01mL 5x0.1mL
EUR 1205

OAAN02231-50UL - PSMB8 Antibody
OAAN02231-50UL 50ul
EUR 149

PSMB8 Antibody, Biotin conjugated
1-CSB-PA018886LD01HU
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  • Ask for price
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OACD05288-100UL - PSMB8 Antibody
OACD05288-100UL 100ul
EUR 199

OACD05289-100UL - PSMB8 Antibody
OACD05289-100UL 100ul
EUR 189

OACD05290-100UL - PSMB8 Antibody
OACD05290-100UL 100ul
EUR 189

OAAN02231-100UL - PSMB8 Antibody
OAAN02231-100UL 100ul
EUR 249

OAAN02231-200UL - PSMB8 Antibody
OAAN02231-200UL 200ul
EUR 389

OAEB02189-100UG - PSMB8 Antibody
OAEB02189-100UG 100ug
EUR 349

OAGA01026-100UL - PSMB8 antibody
OAGA01026-100UL 100ul
EUR 369

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