Genome transfer for the prevention of female

Genome transfer for the prevention of female infertility caused by maternal gene mutation

Poor oocyte quality is associated with early embryo developmental arrest and infertility. Maternal gene plays crucial roles in the regulation of oocyte maturation, and its mutation is a common cause of female infertility. However, how to improve oocyte quality and develop effective therapy for maternal gene mutation remains elusive. Here, we use Zar1 as an example to assess the feasibility of genome transfer to cure maternal gene mutation-caused female infertility. We first discover that cytoplasmic deficiency primarily leads to Zar1-null embryo developmental arrest by disturbing maternal transcript degradation and minor zygotic genome activation (ZGA) during the maternal-zygotic transition.
We next perform genome transfer at the oocyte (spindle transfer or polar body transfer) and zygote (early pronuclear transfer or late pronuclear transfer) stages to validate the feasibility of preventing Zar1 mutation-caused infertility. We finally demonstrate that genome transfer either at the oocyte or at the early pronuclear stage can support normal preimplantation embryo development and produce live offspring. Moreover, those pups grow to adulthood and show normal fertility. Therefore, our findings provide an effective basis of therapies for the treatment of female infertility caused by maternal gene mutation.
genecorner
genecorner

HIV-1 p24 recombinant antigen,

00174-V-01mg 0,1 mg
EUR 321
Description: HIV-1 p24 recombinant antigen.

HIV-1 p24 recombinant antigen,

00174-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 p24 recombinant antigen.

HIV-1 p24 recombinant antigen

8909 100 ug
EUR 608.1
Description: This is HIV-1 p24 recombinant antigen for ELISA,WB.

HIV-1 p24 recombinant antigen

9002 100 ug
EUR 712.5
Description: This is HIV-1 p24 recombinant antigen for ELISA,WB.

Human HIV-1 And HIV-2 Plus P24 Antigen Fourth-Generation (HIV p24 antigen) ELISA Kit

abx257575-96tests 96 tests
EUR 764.4

HIV-1 GAG P24 Recombinant Antigen

00111-V-01mg 0,1 mg
EUR 321
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 GAG P24 Recombinant Antigen

00111-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV type 1 P24

DAG1520 100 µg
EUR 972

HIV Type-1 p24 Antibody

V2344-100UG 100 ug
EUR 349.3
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody

V2344-20UG 20 ug
EUR 153.3
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody

V2344CF488-100T 100 Tests
EUR 349.3
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV Type-1 p24 Antibody

V2344SAF-100UG 100 ug
EUR 349.3
Description: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

HIV 1 p24 core recombinant antigen

00177-V-01mg 0,1 mg
EUR 321
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen

00177-V-1000ug 1000 ug
EUR 1539
Description: HIV 1 p24 core recombinant antigen.

HIV type O envelope antigen

00178-V-01mg 0,1 mg
EUR 321
Description: HIV type O envelope antigen. Synthetic HIV type-O peptide, containing the HIV type-O envelope-derived sequence.

HIV type O envelope antigen

00178-V-1000ug 1000 ug
EUR 1539
Description: HIV type O envelope antigen. Synthetic HIV type-O peptide, containing the HIV type-O envelope-derived sequence.

HIV type 1 P24 [GST]

DAG1516 100 µg
EUR 774

HIV type 1 P24 [His]

DAG1518 100 µg
EUR 774

HIV type 1 P24 [His]

DAG1799 50 ug
EUR 2017.2

HIV type 1 P24 [His]

DAG2375 100 µg
EUR 868.8

HIV type 1 P24 [His]

DAG2377 100 µg
EUR 868.8

HIV type 1 p24 [FITC]

DAGH004 50 Tests
EUR 1112.4

HIV type 1 P24 [Biotin]

DAG1519 100 µg
EUR 972

HIV-P24 antigen array kit

VArk-Lsx001 unit Ask for price
Description: Fourth-generation HIV immunoassays detect viral p24 protein in the blood.

HIV type 1 P24 (p24HXBc2) [His]

DAG2378 100 µg
EUR 1095.6

HIV type 1 P24 (CN54) [His]

DAG2380 100 µg
EUR 1095.6

HIV type 1 P24 (HXBc2) [His]

DAG2376 100 µg
EUR 868.8

Recombinant Human Immunodeficiency Virus Type 1 Antigen, P24

DAG515 1mg
EUR 1444.8

Human HIV(1+2 antibodies plus p24 antigen (4th Generation) ELISA Kit

EH4101 96T
EUR 571.5
Description: Method of detection: Qualitative ;Reacts with: Homo sapiens;Sensitivity: Qualitative

HIV-1 p17/24/gp120 antigen

00169-V-01mg 0,1 mg
EUR 321
Description: HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.

HIV-1 p17/24/gp120 antigen

00169-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 p17/24/gp120 antigen.The protein contains the HIV immunodominant regions from gag p17-p24 gp 120.

HIV-1 intergase antigen

00199-V-01mg 0,1 mg
EUR 321
Description: HIV-1 intergase antigen. The protein contains the HIV-1 immunodominant regions from pol protein (integrase).

HIV-1 intergase antigen

00199-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 intergase antigen. The protein contains the HIV-1 immunodominant regions from pol protein (integrase).

HIV type 1 P24 Capsid Protein (Q23-CxC) [His]

DAG2379 100 µg
EUR 1095.6

HIV-1 tat recombinant antigen

00110-V-01mg 0,1 mg
EUR 321
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 tat recombinant antigen

00110-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 nef recombinant antigen

00112-V-01mg 0,1 mg
EUR 321
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 nef recombinant antigen

00112-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 gag recombinant antigen

8934 100 ug
EUR 542.86
Description: This is HIV-1 gag recombinant antigen for ELISA,WB.

HIV-1 nef recombinant antigen

8941 100 ug
EUR 477.6
Description: This is HIV-1 nef recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen,

00170-V-01mg 0,1 mg
EUR 321
Description: HIV-1 gp41 recombinant antigen.

HIV-1 gp41 recombinant antigen,

00170-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 gp41 recombinant antigen.

HIV-1 gp41 recombinant antigen

8908 100 ug
EUR 673.36
Description: This is HIV-1 gp41 recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen

8933 100 ug
EUR 477.6
Description: This is HIV-1 gp41 recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen

9000 100 ug
EUR 484.13
Description: This is HIV-1 gp41 recombinant antigen for ELISA,WB.

HIV-1 gp41 recombinant antigen

9001 100 ug
EUR 484.13
Description: This is HIV-1 gp41 recombinant antigen for ELISA,WB.

HIV-1 p24 Antibody

7313-002mg 0.02 mg
EUR 206.18
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains.

HIV-1 p24 Antibody

7313-01mg 0.1 mg
EUR 523.7
Description: HIV-1 p24 Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix. The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein. The p24 is the major capsid protein of the virus and has been used in clinical trials as one of the components of the HIV-1 vaccine because of the high degree of sequence conservation between different strains.

HIV-1 p24 Antibody

abx023027-1ml 1 ml
EUR 693.6

HIV-1 p24 Antibody

abx023925-1mg 1 mg
EUR 828

HIV-1 p24 Antibody

abx023926-1mg 1 mg
EUR 828

HIV-1 p24 Antibody

abx021869-1mg 1 mg
EUR 794.4

HIV-1 p24 Antibody

abx021870-1mg 1 mg
EUR 760.8

HIV-1 p24 Antibody

abx021871-1mg 1 mg
EUR 794.4

HIV-1 p24 Antibody

abx021872-1mg 1 mg
EUR 794.4

HIV-1 p24 Antibody

abx021873-1mg 1 mg
EUR 794.4

HIV-1 p24 Antibody

abx021882-1mg 1 mg
EUR 1178.4

HIV-1 p24 Antibody

abx021883-1mg 1 mg
EUR 1220.4

HIV-1 p24 Antibody

abx021886-1mg 1 mg
EUR 1220.4

HIV-1 p24 Antibody

abx021887-1mg 1 mg
EUR 1220.4

HIV-1 p24 Antibody

abx021888-1mg 1 mg
EUR 1220.4

HIV-1 p24 Antibody

20-abx137062
  • EUR 427.20
  • EUR 627.60
  • 0.5 mg
  • 1 mg

HIV-1 p24

E5-00024 1mg
EUR 1152

HIV-1 p24

E62H002 100ug
EUR 458.4

HIV type 1 P17

DAG1542 100 µg
EUR 774

Recombinant Human Immunodeficiency Virus Type 1 Gap P24 Antigen Strain IIIB (a.a. 77-436)

DAG567 0.5mg
EUR 998.4

HIV Type 1 p24 Extended Range Kit (5 x 96 Determinations)

0801137 5 x 96T
EUR 87

HIV Type 1 p24 Extended Range Kit (5 x 96 Determinations)

801137 5 x 96 Determinations
EUR 83

HIV 1 envelope recombinant antigen

00176-V-01mg 0,1 mg
EUR 321
Description: HIV 1 envelope recombinant antigen. HIV-1 evnelope protein spanning the C-Terminus of gp 120 and most of gp 41.

HIV 1 envelope recombinant antigen

00176-V-1000ug 1000 ug
EUR 1539
Description: HIV 1 envelope recombinant antigen. HIV-1 evnelope protein spanning the C-Terminus of gp 120 and most of gp 41.

HIV-1 p17/24/gp120-gp41 recombinant antigen,

00168-V-01mg 0,1 mg
EUR 321
Description: HIV-1 p17/24/gp120-gp41 recombinant antigen.

HIV-1 p17/24/gp120-gp41 recombinant antigen,

00168-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 p17/24/gp120-gp41 recombinant antigen.

ToX Antigen (P24,GRA1)

E61Y00305 1mg
EUR 840

HIV-1 env gp41 recombinant antigen

00113-V-01mg 0,1 mg
EUR 321
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-1 env gp41 recombinant antigen

00113-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-1 gp41 Long recombinant antigen,

00171-V-01mg 0,1 mg
EUR 321
Description: HIV-1 gp41 Long recombinant antigen.

HIV-1 gp41 Long recombinant antigen,

00171-V-1000ug 1000 ug
EUR 1539
Description: HIV-1 gp41 Long recombinant antigen.

Anti-HIV Type 1 p24 Clone 32/5.17.76 (1 mg)

0801124 1 mg
EUR 1985

Anti-HIV Type 1 p24 Clone 38/8.7.47 (1 mg)

0801125 1 mg
EUR 1985

Anti-HIV Type 1 p24 Clone 39/5.1.23 (1 mg)

0801126 1 mg
EUR 2026.85
Description: Please contact Gentaur in order to receive the datasheet of the product.

Anti-HIV Type 1 p24 Clone 39/6.14 (1 mg)

0802014 1 mg
EUR 2026.85
Description: Please contact Gentaur in order to receive the datasheet of the product.

Anti-HIV Type 1 p24 Clone 32/5.17.76 (1 mg)

801124 1 mg
EUR 1890

Anti-HIV Type 1 p24 Clone 38/8.7.47 (1 mg)

801125 1 mg
EUR 1890

Anti-HIV Type 1 p24 Clone 39/5.4A (1 mg)

801136 1 mg
EUR 1890

Anti-HIV Type 1 p24 Clone 39/5.4A (1 mg)

0801136 1 mg
EUR 1985

A novel fumarate, isosorbide di-(methyl fumarate) (IDMF), replicates astrocyte transcriptome responses to dimethyl fumarate (DMF) but specifically down-regulates genes linked to a reactive phenotype

Dimethyl fumarate (DMF) has emerged as a first-line treatment for the relapsing-remitting multiple sclerosis (RRMS) subtype. It is hypothesized that DMF has anti-inflammatory and antioxidant effects although mechanisms are not fully understood. This study used RNA-seq to profile gene expression responses to DMF in cultured astrocytes. Responses were compared with those of isosorbide di-(methyl fumarate) (IDMF), a newly designed fumarate that may partially replicate DMF activity with fewer adverse effects. Both compounds altered the expression of MS-associated genes, including those near MS susceptibility loci and genes dysregulated in MS patient astrocytes.
The shared DMF/IDMF transcriptome response involved altered expression of antioxidant genes (e.g., HMOX1) and genes linked to extracellular matrix integrity (TIMP3, MMP9) and migration of pro-inflammatory cells into CNS (CCL2). IDMF-specific transcriptome responses included down-regulation of mitotic genes associated with a proliferative reactive astrocyte phenotype (ICAM1) and repression of genes encoding NF-kappaB subunits (NFKB2, RELA, RELB) and NF-kappaB targets (NCAPG, CXCL1, OAS3). Overall, these results identify astrocyte-centered mechanisms that may contribute to the established efficacy of DMF as an RRMS treatment. Furthermore, our findings support a rationale for further studies of IDMF as a novel fumarate, which may have unique suppressive effects on astrocyte reactivity and glial scar formation. [200 words].

Changes in peripheral blood oxidative stress markers and hepatic gene expression related to oxidative stress in Holstein cows with and without subacute ruminal acidosis during the periparturient period

We investigated changes in peripheral blood metabolites, oxidative stress markers (malondialdehyde, potential antioxidant capacity, and glutathione peroxidase [GPX]), and hepatic gene expression related to oxidative stress in Holstein cows with and without subacute ruminal acidosis (SARA) during the periparturient period. Eighteen multiparous Holstein cows were categorized into SARA (n=9) or non-SARA (n=9) groups depending on whether they developed SARA; reticulo-ruminal pH was <5.6 for more than 3 hr per day, during the 2 weeks after parturition. Blood and liver tissue samples were collected 3 weeks prepartum and 2 and 6 weeks postpartum, with an additional blood sample collected 0 and 4 weeks postpartum.
Blood aspartate transaminase (AST) and nonesterified fatty acid (NEFA) increased significantly (P<0.05) after parturition in both groups. GPX activity decreased gradually after parturition in the SARA group. In the SARA group, gene expression of GPX 1 and microsomal glutathione S-transferase 3 (MGST3) decreased significantly (P<0.05), and expression of metallothionein 2A increased significantly (P<0.05) after parturition in the SARA group. Superoxide dismutase 1 and MGST3 decreased significantly (P<0.05) 2 weeks postpartum in the non-SARA group. Gene expression related to oxidative stress was negatively correlated with AST, NEFA and total ketone body levels. Therefore, the hepatic gene expression related to oxidative stress might change associated with a negative energy balance, and might relate the high oxidative stress in the SARA group during periparturient period.

PSMB8 Antibody

1-CSB-PA775839
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

PSMB8 Polyclonal Antibody

A73468
  • EUR 377.30
  • EUR 577.50
  • 50 ul
  • 100 ul

PSMB8 Conjugated Antibody

C43134 100ul
EUR 476.4

PSMB8 Antibody, HRP conjugated

1-CSB-PA018886LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

PSMB8 Antibody, FITC conjugated

1-CSB-PA018886LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

PSMB8 Antibody, Biotin conjugated

1-CSB-PA018886LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB8. Recognizes PSMB8 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Monoclonal PSMB8 Antibody, Clone: 1A5

AMM02864G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PSMB8. The antibodies are raised in Mouse and are from clone 1A5. This antibody is applicable in WB and IHC, ICC, E

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211178
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Proteasome subunit beta type-8 (PSMB8) Antibody

20-abx211851
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx114776
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx141396
  • EUR 444.00
  • EUR 727.20
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx011689-100ul 100 ul
EUR 493.2

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

20-abx006453
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-400ul 400 ul
EUR 627.6

Proteasome Subunit Beta Type-8 (PSMB8) Antibody

abx028154-80l 80 µl
EUR 343.2

Psmb8/ Rat Psmb8 ELISA Kit

ELI-15652r 96 Tests
EUR 1063.2

Monoclonal PSMB8 Antibody (monoclonal) (M01), Clone: 1B3

AMM03954G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human PSMB8 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1B3. This antibody is applicable in WB, IHC and IF, IP, E

PSMB8 siRNA

20-abx930156
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 siRNA

20-abx930157
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 siRNA

20-abx904317
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PSMB8 Rabbit pAb

A7340-100ul 100 ul
EUR 369.6

PSMB8 Rabbit pAb

A7340-200ul 200 ul
EUR 550.8

PSMB8 Rabbit pAb

A7340-20ul 20 ul
EUR 219.6

PSMB8 Rabbit pAb

A7340-50ul 50 ul
EUR 267.6

PSMB8 Blocking Peptide

BF0434-BP 1mg
EUR 234

PSMB8 protein (His tag)

80R-2608 100 ug
EUR 386.4
Description: Purified recombinant PSMB8 protein

Canine PSMB8 ELISA KIT

ELI-15651d 96 Tests
EUR 1113.6

Rat PSMB8 shRNA Plasmid

20-abx984734
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse PSMB8 shRNA Plasmid

20-abx971337
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human PSMB8 shRNA Plasmid

20-abx953843
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

PSMB8 Recombinant Protein (Rat)

RP222629 100 ug Ask for price

PSMB8 Recombinant Protein (Mouse)

RP165287 100 ug Ask for price

PSMB8 Recombinant Protein (Human)

RP085356 100 ug Ask for price

Psmb8 ORF Vector (Rat) (pORF)

ORF074211 1.0 ug DNA
EUR 607.2

PSMB8 ORF Vector (Human) (pORF)

ORF028453 1.0 ug DNA
EUR 486

Psmb8 ORF Vector (Mouse) (pORF)

ORF055097 1.0 ug DNA
EUR 607.2

[KO Validated] PSMB8 Rabbit pAb

A19933-100ul 100 ul
EUR 492

[KO Validated] PSMB8 Rabbit pAb

A19933-200ul 200 ul
EUR 685.2

[KO Validated] PSMB8 Rabbit pAb

A19933-20ul 20 ul
EUR 265.2

[KO Validated] PSMB8 Rabbit pAb

A19933-50ul 50 ul
EUR 344.4

PSMB8 ELISA Kit (Dog) (OKEH03975)

OKEH03975 96 Wells
EUR 1012.8
Description: Description of target: ;Species reactivity: Dog;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.064 ng/mL

PSMB8 ELISA Kit (Human) (OKCD02695)

OKCD02695 96 Wells
EUR 950.4
Description: Description of target: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.117 ng/mL

PSMB8 ELISA Kit (Human) (OKEH07770)

OKEH07770 96 Wells
EUR 1310.4
Description: Description of target: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06ng/mL

Psmb8 sgRNA CRISPR Lentivector set (Rat)

K6921501 3 x 1.0 ug
EUR 406.8

Psmb8 sgRNA CRISPR Lentivector set (Mouse)

K4425601 3 x 1.0 ug
EUR 406.8

PSMB8 sgRNA CRISPR Lentivector set (Human)

K1740301 3 x 1.0 ug
EUR 406.8

PSMB8 3'UTR GFP Stable Cell Line

TU069046 1.0 ml
EUR 1672.8

Psmb8 3'UTR GFP Stable Cell Line

TU266964 1.0 ml Ask for price

Psmb8 3'UTR GFP Stable Cell Line

TU167173 1.0 ml Ask for price

PSMB8 Protein Vector (Rat) (pPM-C-HA)

PV296844 500 ng
EUR 723.6

PSMB8 Protein Vector (Rat) (pPB-C-His)

PV296842 500 ng
EUR 723.6

PSMB8 Protein Vector (Rat) (pPB-N-His)

PV296843 500 ng
EUR 723.6

PSMB8 Protein Vector (Rat) (pPM-C-His)

PV296845 500 ng
EUR 723.6

PSMB8 Protein Vector (Mouse) (pPM-C-HA)

PV220388 500 ng
EUR 723.6

PSMB8 Protein Vector (Human) (pPM-C-HA)

PV113812 500 ng
EUR 662.4

PSMB8 Protein Vector (Mouse) (pPB-C-His)

PV220386 500 ng
EUR 723.6

PSMB8 Protein Vector (Mouse) (pPB-N-His)

PV220387 500 ng
EUR 723.6

PSMB8 Protein Vector (Mouse) (pPM-C-His)

PV220389 500 ng
EUR 723.6

PSMB8 Protein Vector (Human) (pPB-C-His)

PV113810 500 ng
EUR 662.4

PSMB8 Protein Vector (Human) (pPB-N-His)

PV113811 500 ng
EUR 662.4

PSMB8 Protein Vector (Human) (pPM-C-His)

PV113813 500 ng
EUR 662.4

PSMB8 3'UTR Luciferase Stable Cell Line

TU019046 1.0 ml
EUR 1672.8

Psmb8 3'UTR Luciferase Stable Cell Line

TU117173 1.0 ml Ask for price

Psmb8 3'UTR Luciferase Stable Cell Line

TU216964 1.0 ml Ask for price

Human Proteasome subunit beta type-8 (PSMB8)

1-CSB-EP018886HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Proteasome subunit beta type-8(PSMB8) expressed in E.coli

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6921502 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6921503 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6921504 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4425602 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4425603 1.0 ug DNA
EUR 184.8

Psmb8 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4425604 1.0 ug DNA
EUR 184.8

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 1)

K1740302 1.0 ug DNA
EUR 184.8

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 2)

K1740303 1.0 ug DNA
EUR 184.8

PSMB8 sgRNA CRISPR Lentivector (Human) (Target 3)

K1740304 1.0 ug DNA
EUR 184.8

Recombinant Human PSMB8 Protein, His, E.coli-1mg

QP13190-1mg 1mg
EUR 3308.4

Recombinant Human PSMB8 Protein, His, E.coli-5ug

QP13190-5ug 5ug
EUR 186

Recombinant Human PSMB8 Protein, His, E.coli-20ug

QP13190-20ug 20ug
EUR 241.2

PSMB8 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV700471 1.0 ug DNA
EUR 616.8

PSMB8 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV700475 1.0 ug DNA
EUR 616.8

PSMB8 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV700476 1.0 ug DNA
EUR 616.8

PSMB10 antibody

70R-19581 50 ul
EUR 522
Description: Rabbit polyclonal PSMB10 antibody

PSMB11 antibody

70R-19582 50 ul
EUR 522
Description: Rabbit polyclonal PSMB11 antibody

PSMB10 antibody

70R-5872 50 ug
EUR 560.4
Description: Rabbit polyclonal PSMB10 antibody

PSMB10 antibody

38658-100ul 100ul
EUR 302.4

PSMB10 Antibody

1-CSB-PA018877ESR1HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PSMB10. Recognizes PSMB10 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

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